Silicosis is a debilitating miners disease that results from

Silicosis is a debilitating miner\'s disease that results from the ingestion of silica particles (such as sand or glass) by macrophages in the lungs. Asbestosis is a similarly serious disease caused by inhalation of asbestos fibers. In both cases, the particles or fibers are found in lysosomes. and fibroblasts, which secrete collagen, are stimulated to deposit nodules of collagen fibers in the lungs, leading to reduced lung capacity, Impaired breathing, and eventually death. Part B What effect do you think fiber or particle accumulation has on the lysosomes? The fibers or particles may chemically modify the lysosomal membrane, causing it to become leaky. The fibers or particles may physically mitigate the lysosomal membrane, causing it to become firm. The fibers or particles may physically abrade the lysosomal membrane, causing it to become leaky. The fibers or particles may chemically modify the lysosomal membrane, causing it to become firm. Part C How might you explain the death of silica-containing or asbestos-containing cells? Cell death is probably due to the adsorption of acid hydrolases on damaged lysosomes. Cell death is probably due to the digestion of cellular components by acid hydrolases that escape from damaged lysosomes. Cell death is probably due to the digestion of cellular components by alkali that escape from damaged lysosomes. Cell death is probably due to the adsorption of cellular components by acids that escape from damaged lysosomes.

Solution

Part B:

Correct answer is:The fibers or particles may physically abrade the lysosomal membrane, causing it to become leaky.

Reason:The silica and asbestos particles wear away the lysosomal membrane which makes them leaky.

Part C:

Correct answer is:Cell death is probably due to digestion of cellular components by acid hydrolases that escape from damaged lysosomes.

Reason: Acid hydrolases released due to damaged lysosomal membrane causes autophagy of cellular components.