A patient was admitted for surgery with a history of a previ

A patient was admitted for surgery with a history of a previous anti-U. You are directed to test this patient’s siblings because U-negative donor units are rare. No commercial antiserum is available for testing. What other source of anti-U could you use to phenotype the patient’s siblings?

Solution

The anti-U antibodies are significantly IgG antibodies that may reduced red blood cell survival. The U-antigen is an high incidence antigen occurs in 99% of population. Normally, the probability of anti-U presence can be examined whether the person is \"s\" or \"S\" antibody. So that, in the above case, patient was admitted for surgery with a history of a previous anti-U. You are directed to test this patient’s siblings because U-negative donor units are rare. No commercial antiserum is available for either testing then other source of anti-U can be detected if there is inheritance os \"S\" or \"s\" therefore, it is essential to use anti-S or anti-s antibodies for phenotype to know the patient’s siblings