Which of the following is NOT a component of normal RasMAPK

Which of the following is NOT a component of normal Ras-MAPK signaling? Raf activation MEK phosphorylation Cyclin transcription Mdm2 kinase activity Which of the following is true? The Abl kinase is commonly overexpressed in its normal form in cancer. Fusion proteins are the most common type of oncogenic MYC mutations. Burkitt\'s lymphoma is a virally-induced cancer in humans. Oncogenic mutations in BCL2 are found in roughly 2/3 of human melanomas. Which of the following mutations is NOT likely to be oncogenic? DNA inversion in which an RTK gains a dimerization domain. A point mutation that increases the GTPase activity of Ras. A translocation that places MYC adjacent to a strong promoter Gene amplification resulting in multiple copies of BCL2.

Solution

Q6. Components of normal Ras-MAPK signaling are:
Raf activation
MEK phosphorylation
Cyclin transcription

Not

Mdm2 kinase activity

As in Ras-Raf-MEK-ERK pathway, Ras get activated and attaches Raf (serine/threonine kinase) which helps MEK phosphorylation, induces Cyclin transcription but Mdm2 kinase activity is abnormal and associated with invasion, cancer and apoptosis.

Q7. The statement stating \"Burkitt\'s lymphoma is a virally induced cancer in humans\" is true.

Ab1 kinase is not commonly overexpressed in its normal form in cancer but in case of viral induction

Fusion proteins are not the most common type of oncogenic MYC mutations

Oncogenic mutations in BCL2 are not found in as high as 2/3 of human melanomas.

Q8. A point mutation tha increases the GTPase activity of Ras is not a potential oncogenic mutation

DNA inversion in which an RTK gains a dimerization domain have oncogenic potential

A translocation that places MYC adjacent to a strong promoter neurofibromatosis (NF1) has potential oncogenic ability

Gene amplification resulting in multiple copies of BCL2 oncogenic