Makers of generic drugs must show that they do not differ si

Makers of generic drugs must show that they do not differ significantly from the reference drugs that they imitate. One aspect in which drugs might differ is their extent of absorption in the blood. Table 20.5 gives data taken from 20 healthy nonsmoking male subjects for one pair of drugs. This is a matches pairs design. Numbers 1 to 20 were assigned at random to the subjects. Subjects 1 to 10 received generic drug first, followed by the reference drug. Subjects 11 to 20 received the reference drug first, followed by the generic drug. In all cases, a washout period separated the two drugs
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