Which of the following is true of RAS It was originally iden

Which of the following is true of RAS? It was originally identified from a mouse retrovirus. Activated Ras binds ADP. HRAS is the most commonly mutated RAS gene in human cancers. Oncogenic RAS mutations typically eliminate its GTPase activity. Which of the following statements about growth factor signaling and cancer is true? Deletion of an RTK\'s growth factor binding site is a common oncogenic mutation. Gene amplifications of GAPs are common oncogenic mutations. Jak dimers enter the nucleus and activate proliferation genes. Amplification of MAPK in breast and ovarian cancer results in highly increased levels of MAPK on the cell surface. Which of the following is NOT a component of normal Ras-MAPK signaling? Raf activation MEK phosphorylation Cyclin transcription Mdm2 kinase activity

Solution

question 4.

C HRAS is most commonly mutated gene in human cancers

HRAS has been shown to be a proto-oncogene. When mutated, proto-oncogenes have the potential to cause normal cells to become cancerous

Question 5

deletion of RTKs growth factor binding site deletion is a common oncogenic mutation.

The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive and aberrant activations of components of those pathways result in increased proliferation, survival and metastasis.

Question 6.

Cyclin transcription

It is not a part of normal Ras-MAPK Signaling pathway but Ras MAPK regulate the Cyclin transcription .