In a human study looking at the applicability of synthetic p

In a human study looking at the applicability of synthetic progesterone to fix the deficiencies and malfunctioning due to certain toxic exposures. The NOEL in the human subject has been approximated as 12 mug/kg per work day; if a safety factor of 8 is assumed with a breathing rate of 10 m^3 in 8 hours, and the OEL for the substance has been determined as 11.4 mug/m^3, what is the subject\'s body weight?

Solution

Subject\'s body weight = (OEL/NOEL)*(Breathing Rate)*Safety Factor.

We have:

NOEL = 12 ug/kg

OEL = 11.4 ug/m^3

Breathing rate = 10 m^3(/8 hour)

Safety factor = 8

Therefore, Weight = (11.4/12)*(10)*8

Weight = 76 kgs.