Why is a angle base pair deletion mullion within prelim coding sequence more aioli to be harmful than base per change muleteer? Single base-pair deletions make amino acid sequence snarled. a single base-pair change just change the sequence. Single base pair deletions lead to changing the amino acid in the portion that cause changing of functions others protein. A single base pair change may not even charge the amino acid, and it does. If is possible the single amino acid change within a protein can be tolerated. Single base-pair dilations change the codon to one that sepias a stop codon. This cause early termination of the chalk and a most always results in a protein. A single base-pair change also may change the coda to one that specifies a stop cede, built it happens more rarely Single base-pair deletions shift the reading trine and jumble the message at all points after the mutations. A single base-pair change may not even change the amino acid, and if it does, Fids possible the single amino acid change within a protein can be lowered.
Answer is 4. Singl base pair deletion completely shift the reading frame on the m RNA, this leads to change the amino acids sequence from that deleted base codon when it is get translated. So the whole sequence of the protein or peptide changes and its function also changes. Where as mutation in single base, does not leads to frame shift. So the amino acid sequence will not change in entire protein, but only the mutated codon amino acid only change. More over most of the codons are synonymus codons, if mutation leads to formation of synonymous codon, there is no change in the amino acid sequence. So no effect on the protein. So mutation show less effect on protein function, where as deletion is fatal for the entire protein.
The above explanation is based on the properties of Genetic code: 1. Genetic code is comma less; 2. Genetic code is non overlapping
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