What happens to ACTH levels if someone uses a lipoxygenase i

What happens to ACTH levels if someone uses a lipoxygenase inhibitor? Explain.

Solution

ACTH levels fall when someone uses lipoxygenase inhibitor. Lipoxygenase is involved in CRF stimulated ACTH release.

CRF rise leads to the production of arachidonic acid which stimulates ACTH. Lipoxygenase inhibitors block the CRF and hence the net result will be decrease in ACTH levels.