Drug craving is thought to be associated with A decreased GA

Drug craving is thought to be associated with:

A. decreased GABAergic reactivity.
B. Up-regulation of dopamine receptors.
C. Down-regulation of GABA receptors.
D. increased glutamatergic reactivity.

Solution

   D. increased glutamatergic reactivity.

Dopamine release associated with the increased glutamatergic activity is responsible for drug craving. Dopamine is expected to involve in the drug dependence through the “mesocortical dopaminergic reward pathways.” The dopamine releasing drugs such as amphetamine and cocaine were shown to activate these pathways.