A patient with a bloodborne infection caused by Pseudomonas

A patient with a bloodborne infection caused by Pseudomonas aeruginosa, a Gram negative bacterium, was treated with the antibiotic gentamicin that lyses the cells. After treatment, the Pseudomonas could not be cultured from his blood, indicating that the bacteria were killed. However, his symptoms worsened. Explain why antibiotic treatment made his condition worse. Your answer must include the following terms in the proper context: cytokines, cell wall, sepsis, macrophage, vasodilation, endotoxin, hypotension, tachycardia, edema, lipid A, thrombi, coagulation, multiple organ system failure.

Solution

The antibiotic gentamicin that lyses the cells including the phagocytosed by cytokine-mediated macrophages (innate and adaptive immune system activities) with Pseudomonas aeruginosa and endotoxins release by this Gram-negative bacterium so that even though bacterial species has killed, there are other aspects of side effects such as \"pus formation with oedema\". These side effects such as tachycardia and persistent cardiovascular effects due to release of cell detritive species after phagocytosis finally causes hypotension and vasodialtion. Sometimes, these cellular debris is also leading to abnormal coagulation events iun which due to formation of thrombus result in organ failure (heart failure due to lipid -oriented thrombus formation)