Suppose the frameshift mutation was still present but now th

Suppose the frameshift mutation was still present, but now there was a base substitution (A to C) in the arginine (R) codon, changing it from AGA to AGC. Original Sequence: 5\' - UG | GUC | GGC | GAG | AAC | GAA | AGC | GC - 3\' Mutated Sequence: 5\' - UG | GUC | GGG | AGC | ACG | AAA | GCG | C - 3\' Would the function of the protein be restored? Choose the best answer. A. No, while the serine is present in the protein, the rest of the mRNA is still out of frame. B. Yes, the reading frame has been restored and now the serine can be phosphorylated. C. Yes, now the serine can be phosphorylated. D. No, while the serine is is present, it is not in the same location as the original protein. Even though the rest of the protein is functional, shifting the amino acid a few positions would likely not allow it to be phosphorylated.

Solution

The correct answer is option A.

A. No, while the serine is present in the protein, the rest of the mRNA is still out of frame.

No, while the serine is present, in the protein, the rest of the mRNA is still out of frame. Even though the rest of the protein is functional, shifting the amino acid a few positions would likely not allow it to be phosphorylated. The reason for this could be as the 5\' carbon has a phosphate group attached to it and the 3\' carbon a hydroxyl group. For seine to be phosphorylated ,it has to be at 5\' carbon after frsmeshift mutation.