The amino acids serine glutamate and phenylalanine were foun

The amino acids serine, glutamate, and phenylalanine were found to be important binding groups in a receptor binding site. The triplet codes for these amino acids in the mRNA for tis receptor were AGU, GAA, and UUU respectively. Explain the effect the following mutations might have if any:

AGU to ACU

AGU to GGU

AGU to AGC

GAA to GAU

GAA to AAA

GAA to GUA

UUU to UUC

UUU to UAU

UUU to AUU

UUU to AAU

Solution

Mutation

AGU to ACU : Serine to Threonine mutation. Since serine is an important receptor binding site amino acid, The receptor can no longer bind to the protein because of change in the active site composition.

AGU to GGU:Serine to Glycine mutation causes A>G mutation with siilar effect as above, i.e change in the active site composition

AGU to AGC Serine>Serine U>C mutation is a silent mutation causes no change to the binding site

GAA to GAU Glutamic acid >Aspartic acid A>U mutation causes change in second amino acid of core binding site protein.

GAA to AAA Glutamic acid> Lysine G>A mutation

GAA to GUA Glutamic acid>Valine A>U mutation

UUU to UUC : Phenylalanine > Phenylalanine U>C mutation is a silent mutation causes no change in the protein

UUU to UAU: Phenylalanine > Tyrosine U>A mutation causes change in protein sequence

UUU to AUU Phenylalanine>Isoleucine U>A mutation change in protein sequence

UUU to AAU:Phenylalanine> Asparagine UU>AA is a dinucleotide mutation causing change in the sequence causing the binding site composition to change