If you had a loss of function mutation in the methylated DNA

If you had a loss of function mutation in the methylated DNA binding protein MECP2, what pattern of activity (if any) would you expect to see in your imprinted genes? How does this differ (if it does) from the pattern of activity you are supposed to have in these genes?

Solution

MECP 2 gene encodes for protein MECP 2. This protein is generally known to be involved in silencing of or repressing the genes thus inhibiting their activity when not needed. This protein falls under the category of proteins that bind to methylated DNA and repress the transcription of that gene.

Mutation in this gene causes neurological disorders. As mutation in this gene will not allow it to repress the activity of unwanted genes. Generally a syndrome named as Rett syndrome is associated with mutation in this gene.