Which of the following statements about genomewide associati

Which of the following statements about genome-wide association studies are true? THERE CAN BE MORE THAN ONE TRUE ANSWER

a) Genome-wide association studies based on the trio design would be least appropriate when severe population structure is apparent.

b) In Drosophilia, there is almost no linkage disequilibrirum (even between adjacent SNPs). Therefore, a strong association in Drosophilia for a given SNP likely indicates thast the SNP is causal (functional) SNP for the phenotype being studied

c) in performing genome-wide association studies in Arabidopsis, fewer tag SNPs would be needed in centrometric regions (that is, the DNA in and around centromeres)

d) in genome-wide association studies, detection of rare alleles as causal for trait variation is typically only possible if the rare alleles have a very large impact on phenotypes

e) in a genome-wide association study, taking the negative log of the P-value is a required step to assess statistical significance.

Solution

Ans:

a) Genome-wide association studies based on the trio design would be least appropriate when severe population structure is apparent.

d) in genome-wide association studies, detection of rare alleles as causal for trait variation is typically only possible if the rare alleles have a very large impact on phenotypes