What is the link between CCR5 receptor and the West Nile Vir

What is the link between CCR5 receptor and the West Nile Virus? Would you give Africans CCR5 blocking drugs? Why/Why not?

Solution

The link between CCR5 receptor and the West Nile Virus:

Chemokine receptor type 5 (CCR5) is main receptor occupied by macrophage-tropic HIV to attach to a new immune cell. Cluster differentiation 4 (CD4) are the primary cell surface receptor for HIV. CD4 cell surface is the docking area for HIV. Delta 32-mutation of CCR5 provide resistance to diseases caused by very different organisms such as HIV and bubonic plague because mutated CCR5 is going to produce a smaller receptor protein outside of the immune cells result in inability of “HIV or Bactrium Yersinia pestis that cause bubonic plague” to bind to CCR5 co-receptor protein.

The link between CCR5 receptor and the West Nile Virus is CCR5 meticulously mediate “resistance to symptomatic West Nile Virus”. This is due to the activity of CCR5 is mainly as the major HIV coreceptor. Therefore, it is essential to have CCR5 activity & deficiency of CCR5 may leading to higher chances of WNV infection with increased risk. Those African populations, who are more prone to “tick bites” which propagate this WNV infection one human host to another result in infection so that CCR5 blocking drugs are not beneficial because presence active CCR5 can reduced WNV infection. However, those Africans, who are suffering from HIV/ADIS & WNV infection should not be given CCR-5 blocking agents because of it may leading to higher incidence of WNV due to blockade of CCR-5

? Would you give Africans CCR5 blocking drugs