1 Which of the following are potential mechanisms for second

1. Which of the following are potential mechanisms for secondary hyperalgesia?

A. potentiation at the peripheral end of the nociceptor
B. convergence of nociceptors and mechanoreceptive neurons onto the WDR cells of the spinal cord
C. excess glutamate present at the WDR neurons of the spinal cord due to lack of glutamate uptake by astrocytes
D. A&B
E. B&C

2. Sympathetic and DRG neurons arise from which group of neural crest cells?

A. Cranial
B. Vagal
C. Trunk
D. Sacral
E. All the above

A. potentiation at the peripheral end of the nociceptor B. convergence of nociceptors and mechanoreceptive neurons onto the WDR cells of the spinal cord C. excess glutamate present at the WDR neurons of the spinal cord due to lack of glutamate uptake by astrocytes D. A&B E. B&C 2. Sympathetic and DRG neurons arise from which group of neural crest cells? A. Cranial B. Vagal C. Trunk D. Sacral E. All the above

Solution

Option A is correct. Secondary Hyperalgesia finds only in outside the injury site. Potentiation of peripheral terminal of nerves cause Hyperalgesia which includes both primary and secondary types. and affects peripheral Primary hyperalgesia Option C is correctSympathetic and DRG neurons arise from trunk neural trust which is present in between vagal and sacral neural crest. The crest has two groups of cells in which one group divides into Sympathetic and DRG neurons. The other group forms melanocytes.