How can knowledge of gene regulation be used to cure disease

How can knowledge of gene regulation be used to cure diseases?
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Solution

So many genetic diseases occuring in the scenario;probably due to regulations in gene activity.Gene therapy is a means of treating diseases based on modifying the expression of a person\'s genes towards the therapeutic goal. Gene therapy could be used in treating lethal debilitating diseases and also may have the potential for preventing diseases.There are two forms of gene therapy which potentially could be used, Somatic gene therapy and Germline gene therapy. Somatic gene therapy involves the manipulation of gene expression in cells that will be corrective to the patient but not inherited in the next generation. Germline therapy involves the genetic modification of germ cells that will pass the change on to the future generations.Through gene therapy many individuals suffering from several different diseases potentially could be treated and relieved from their suffering that these diseases cause. Gene therapy gives promise in treating individuals living with such diseases as PKU, cardiovascular disease, ADA, AIDS, and many more.for eg:

Hemophilia
Patients born with Hemophilia are not able to induce blood clots and suffer from external and internal bleeding that can be life threatening. In a clinical trial conducted in the United States , the therapeutic gene was introduced into the liver of patients, who then acquired the ability to have normal blood clotting time. The therapeutic effect however, was transient because the genetically corrected liver cells were recognized as foreign and rejected by the healthy immune system in the patients. This is the same problem faced by patients after organ transplantation, and curative outcome by gene therapy might be achievable with immune-suppression or alternative gene delivery strategies currently being tested in preclinical animal models of this disease.

Cancer
Multiple gene therapy strategies have been developed to treat a wide variety of cancers, including suicide gene therapy, oncolytic virotherapy, anti-angiogenesis and therapeutic gene vaccines. Two-thirds of all gene therapy trials are for cancer and many of these are entering the advanced stage, including a Phase III trial of Ad.p53 for head and neck cancer and two different Phase III gene vaccine trials for prostate cancer and pancreas cancer. Additionally, numerous Phase I and Phase II clinical trials for cancers in the brain, skin, liver, colon, breast and kidney among others, are being conducted in academic medical centers and biotechnology companies, using novel technologies and therapeutics developed on-site.