Homework SourseGo to the IRIS website and determine the oral reference dose
Go to the IRIS website and determine the oral reference dose for non-cancer effects, the uncertainty factor used to determine this RfD, the weight of evidence descriptor for cancer assessment, and the cancer oral slope factor (if available) for: arsenic, naphthalene, and benzene
Solution
The detais obtained from the website are as follows:
4.0 x 10-3mg/kg/day
| compound | RfD | Uncertainity Factor | Cancer oral slope factor |
|---|---|---|---|
| Arsenic | 3.0 x10-4mg/kg/day | 3 | 1.5 per mg/kg-day |
| Naphthalene | 2.0 x 10-2mg/kg-day | 3000 | N.A |
| Benzene | 4.0 x 10-3mg/kg/day | 300 | 1.5 x 10-2 to 5.5 x 10-2per (mg/kg)/day |
