On average how often would the nucleotide sequence CGAT occu

On average how often would the nucleotide sequence CGAT occur in a single DNA strand 768 bases long?

Retroviruses like HIV have an RNA genome. During viral reproduction, there is a stage in which viral DNA is integrated in the host cell. What protein makes this possible? If you design a drug that targets and destroys the protein responsible for this integration, will that same drug prevent retroviruses from entering the cell?

Solution

On average how often would the nucleotide sequence CGAT occur in a single DNA strand 768 bases long?

Answer:

we know that there are total four types nucleotides that constitutes whole DNA sequence.

So the average chance of CGAT (4 nucleotide bases) occur in a single DNA strand of 768 long = 768 / 4⁴ = 3

Retroviruses like HIV have an RNA genome. During viral reproduction, there is a stage in which viral DNA is integrated in the host cell. What protein makes this possible?

Answer:

The integration of HIV DNA into the host DNA is a critical step in the HIV life cycle. HIV’s enzyme for inserting the DNA version of its genome into the host cell DNA is called its \"integrase\". HIV-1 integrase catalyzes the “cut-and-paste” action of clipping the host DNA and joining the proviral genome to the clipped ends.

If you design a drug that targets and destroys the protein responsible for this integration, will that same drug prevent retroviruses from entering the cell?

Answer:

No, integrase enzyme is only help the virus in integration of its genome to the host genome.

The HIV virion enters macrophages and CD4⁺ T cells by the adsorption of glycoproteins on its surface to receptors on the target cell followed by fusion of the viral envelope with the cell membrane and the release of the HIV capsid into the cell.