Hurler syndrome is an autosomal recessive disease in which m

Hurler syndrome is an autosomal recessive disease in which mucopolysaccharides accumulate in body tissues, leading to moderate dwarfism, grotesque facial appearance, joint contractures, mental retardation, and early death. Suppose that the mutation rate of gene H (normal) to gene h (Hurler syndrome) is about .9 X 10-5. A. No effective medical treatment is currently available for this condition. What is the expected equilibrium frequency of gene h? How many cases of Hurler Syndrome will occur each generation in a population of 10 million? (1 pt.) B. Suppose a medical treatment is developed that allows children with Hurler syndrome to survive and reproduce so that the fitness of these individuals increases to 0.5. In this situation, what is the expected equilibrium frequency of gene h, and how many cases will occur each generation in a population of 10 million? (1 pt.)

Solution

Answer:

Hurler syndrome is an autosomal recessive disease in which mucopolysaccharides accumulate in body tissues, leading to moderate dwarfism, grotesque facial appearance, joint contractures, mental retardation, and early death.

What is the expected equilibrium frequency of gene h?

Suppose that the mutation rate of gene H (normal) to gene h (Hurler syndrome) is about .9 X 10^-5

The expected frequency of gene h (Hurler syndrome) is approximately 1 in 10⁵ number of population (1 million)

How many cases of Hurler Syndrome will occur each generation in a population of 10 million?

As the expected frequency Hurler syndrome is 1 in 1 million population. So in a population of 10 million, there would be 10 cases of Hurler syndrome occur in each generation.