Explain why it is logical that cisacting sequences that help

Explain why it is ‘logical’ that cis-acting sequences that help enhance gene transcription rates are located upstream of the promotor, while the cis-acting sequences for negative effectors or repressors are typically located downstream, or even within, the promoter region of the gene.

Solution

Cis-acting sequences that help enhance gene transcription rates are located upstream of the promotor, to achieve maximum rates of transcription and gene regulation by RNA polymerase II. whereas repressors inhibit activators and reduce transcription.