To utilize ketone bodies a tissue must have a functioning Gl

To utilize ketone bodies, a tissue must have a functioning: Gluconeogenesis pathway; Glycolysis pathway; Krebs cycle; Malate-aspartate shuttle system; Pyruvate dehydrogenase.

Solution

Acetoacetate, betahydroxy buterate, acetone are known as ketone bodies. it is utilized in tissue by the KREB or TCA cycle. with the formation of Acetyl CoA the TCA cycle begins. Acetyl CoA is produced from ketone body in 3 step pre reaction;

1.3 Hydroxybutanoate+ NAD+ = H+ +NADH +Acetoacetate

2. Succinyl coA + Acetoacetate= Succinate+ Acetoacetyl coA

3. coA + Acetoacetyl coA= Acetyl coA.

BRAIN SPECIALLY UTILIZES KETONE BODY.