Please explain below questions of thermodynamica in your own

Please explain below questions of thermodynamica in your own 3-4 sentences.

Why is O-H or O-P (weak bonds) a better source of energy than H2O (strong bonds)? How can a reaction with a positive loang GO\' (like malate loang oxaloacetate) go forward in the cell? Why do activated states rarely occur at physiological temperatures? How do cells overcome this? What role do enzymes play in the cell with regards to chemical reactions? Can they work against equilibrium? Why are ATP\'s phosphoanhydride bonds high energy? Why is ATP hydrolysis to be so favorable? Peptide bond formation has a positive loang G. What is ATP\'s role in making protein synthesis favorable?

Solution

ATP is a high energy phosphate which is highly unstable that breaks into ADP and Pi known as phosphoanhydride molecules. ATP while being broken down releases high amount of free energy , Delta G⁰ = -7.3 kCal/mol

Delta G⁰ during unfavourable conditions proceeds the reaction forward with a positive values (endothermic reaction).

Enzymes are the catalysts that speed up the rate of the reaction. It doesnot change the equilibrium of the reactants and products.