How does the transport of the nutrients affect the developme

How does the transport of the nutrients affect the development of tissue-engineered vessels in the research laboratory?

Solution

The engineered tissues generally are lack of blood vessels. They typically receive the nutrients and blood by means of molecular diffusion so, it is difficult to form and supply oxygen and nutrients to the deeper tissues.

However, after implantation, these tissues do need vascular supply. So, the organised vasculature network in these tissues is typically included in the laboratory itself. So, the angiogenesis is induced in these tissues by supply appropriate growth factors and nutrients. If the oxygen and nutrient delivery is compromised, tissue implantation fails. On the other hand, excess angiogenesis must also be avoided as it leads to abnormal cell growth.