Methylated is particularly prone to mutation from deaminati

Methylated _______ is particularly prone to mutation from deamination.

guanine

adenine

thymine

uracil

cytosine

Solution

\"Methylated Cytosine is particularly prone to mutation from deamination.\"

Explanation:

Methylated Cytosine is unstable in DNA. Methylated CpG (mCpG) are regarded as mutational hotspots. Methylated C deaminates to thymidine. Mismatch repair machinery does not discriminate against T and C then, and 5-Methylcytosine is incorporated in the nucleoside 5-methylcytidine.Thus the DNA sequence is not altered, but the expression of methylated genes can be altered.

The spontaneous deamination of cytosine result in formation of uracil, and is recognized and removed by DNA repair enzyme; deamination of 5-methylcytosine result in formation of thymine. Thus this conversion of a DNA base from cytosine to thymine result in a transition mutation.