Homework SourseA What is the amino acid sequence of the peptide in pic Writ
A. What is the amino acid sequence of the peptide in pic? Write down the one letter and three letter abbreviation
B. Could the peptide in A be phosphorylated? If so where?
C. Could the peptide in A participate in disulfide bonds? Explain
D. Design a peptide 12 amino acids long that could be a strand within an amphipathic beta sheet. Use 1 letter abbreviations to represent protein
Solution
Answer:
A. The one letter code is: S - C - I - E - N - C - E - Y
The three letter code is: Ser - Cys - Ile - Glu - Asn - Cys - Glu - Tyr
B. Yes. It can be phosphorylated at Ser and Tyr residues. It has been discovered recently that Cys can also undergo phosphorylation.
C. Yes. The two Cys at 2 and 6 positions can form a disulfide bond.
D. Because the side chains of the amino acids alternately project above and below the sheet, a sequence that could form a strand in an amphiphatic b-sheet should have alternating hydrophobic and hydrophilic amino acids.
T-L-N-I-S-F-Q-M-E-L-D-V
