When considering its strength why are the immune hallmarks o

When considering its strength, why are the immune hallmarks of cancer more impotant than the acquisition of specific genome chnages?

Solution

Answer:

The transformation of normal cells to cancer (malignant or tumor) cells occurs in a series of steps, Hanahan and Weinberg listed six alterations essential for malignant growth which refer to as \'The Hallmarks of Cancer\'. The ability to deal with immune mechanisms, however, was not included among these essential capabilities, but may be supposed to be acquired by most—and perhaps all—tumors. Later Weinberg and Hanahan proposed new such immune hallmarks that certainly cancer cells should acquire on their way to giving rise to a tumor. Three such immune hallmarks are certainly required:

These three capabilities and acquisition of the genetic changes required to put them into practice are constant and essential features of natural and experimental cancers. Their strength, however, may vary from one kind of tumor to another, and even more variable are the mechanisms through which the various types of cancer undertake these activities. Acquisition of a specific genome change, therefore, is not important, whereas acquisition of these capabilities is crucial, irrespective of the mechanisms involved.