Ghicose6phosphaln dehydrogenase G6PO deficiency is Inherited

Ghicose-6-phosphaln dehydrogenase (G6PO) deficiency is Inherited as an X inked recessive gene in human\'s A woman whose father suffered from G6PD marries a normal man What proportion of their sons is expected to be G6PD? Express your answer as a fraction, Example: 1/4

Solution

Glucose-6-Phosphate dehydrogenase deficiency is inherited as X-linked recessive gene in humans. A woman whose father suffered from G6PD deficiency marries a normal man. The proportion of sons expected to have G6PD deficiency will be;

Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is also known as favism (after the fava bean).

G6PD deficiency is a genetic disorder that occurs most often in males. This condition mainly affects red blood cells whose function is to carry oxygen from the lungs to tissues throughout the body. In affected individuals, there is a defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely. The destruction of RBCs is called hemolysis.

Explaination:

If the woman\'s father was G6PD deficient and if we assume her mother was either a carrier or normal, the woman must be a carrier because she inherited the X chromosome her father. That X chromosome has the mutation. If she (a carrier) marries a normal man (XY) their sons have a 50% or 1/2 chance of carrying the mutation because they inherit one X chromosome from the mother which can either be the X with mutation or without mutation and Y from the father which do not carry the gene anyways.

After doing the Punnet square, the answer is ½.

This is a cross between a woman with X(A)X(a) and a male with X(A)Y:

Punett Square : Carrier Female XX^a × Normal Male XY

50% of the boy babies and 50% of the girl babies will carry the abnormal chromosome. The boys will have G6DP deficiency and girls will be carriers for G6DP deficiency.

XX	XY
XXa	XaY