1Describe the Stop transfer sequence 2What does calnexin do

1.Describe the \"Stop - transfer sequence\"

2.What does calnexin do and how?

3.What is dolichol? How does it work?

Solution

thanks for the question.
The cells in our body have a life span. Therefore for every cell that breaks down and is eliminated a new one has to be produced. This happens with all types of cells in the body including in the membranes or the outer surface of the cell. During this process, a polypeptide chain has to pass through a membrane channel known as the translocon. However, when a peptide containing a stop sequence inserts into this channel, the process stops. however, the body manages to push the stop sequence laterally into the cell membrance and hence it become s a part of the cell membrane which is made up of lipids. thus a new constituent of the cell membrance has been infused into the cell.
Calnexin acts as a chaperone in the production and elimination of proteins. As proteins are being synthesisized in the body, calnexin provides a check on them to find out if they are appropriately produced so that they can be retained or be eliminated from the body. It does so by bindiong to the defective proteins and helping in their degradation.
Dolichol acts as an anchor in the translation process which is a method of production of proteins in the body. It works as a medium where by carbohydrate chains are built on dolichol, and later transferred to produce proteins in the endoplasmic reticulum.
Thanks