Can someone please help me answer this question Below is a t

Can someone please help me answer this question?

Below is a table listing the amino acids and their corresponding codons. Below the table is a hypothetical protein sequence comprising fifteen codons. Which of the mutations below would have the largest effect (biggest and/or most changes)?

TIT Phe TTC TCC Ser TGT TAC TTA Leu TCA TTG TCG TAA Stop TGG TAG TGA Stop Trp CAT His CGT Pro CAC Arg CAA CGA. CTC Leu CTA CTG CAG AGI Ser ACT ATC Ile AAC ATA ACA AGA. Arg ATG Met ACG AAG GAT Asp GGT GAC Gly GGA GCT GTC Val GTA GCA GTG GAG ATG GAA TGG GGG AGT TGT TAT GTC TTC CCC AAA GGT GGT TGG TAG 3 4 5 6 7 9 10 11 12 13 14 15

Solution

The three stop codons are UAG, UGA and UAA.

A single base mutation in the following codon will have the maximum effect-

GAA- Glu.

Mutation of G to U will stop the codon.