There are three possible fates for immature B cells with IgM

There are three possible fates for immature B cells with IgM that recognizes self-antigens...

Under what circumstances would a self-reactive cell undergo receptor editing?

Solution

This process occurs during B cell maturation and it is a part of adaptive immune system. B cells with autoreactive receptors have a chance to bypass negative regulation by “editing” the specificities of their receptors with additional antibody gene. In order to rescue them from apoptosis. It is thought that B cells have undergone receptor editing making it the most common method of removing self reactive B cells. It is important process that prevent autoimmune disease.