1 What effect would albumin administered IV have on blood vo

1. What effect would albumin administered IV have on blood volume?

2. Would removing the A ag from type A donor blood cells change the pool of potential 6 recipients? (only consider Ab in recipient blood types)

Solution

1. In plasma of the blood, Albumin is a soluble and globular protein that acounts upto 70 - 80% and maintains colloid osmotic pressure.Albumin is distributed in the extracellular water and is found in extravascular fluid. The halflife of albumin in circulation is about 15 to 20 days. Albumin administered IVis to draw approximately 3.5 times its volume of additional fluid into the circulation within 15 minutes. The additional fluid dilutes the hemoconcentration to decrease blood viscosity. The hemodilution lasts for a short period when Human Albumin is administered to individuals having normal blood volume. The minimum plasma albumin level required to prevent peripheral edema is unknown and it varies from patient to patient. Approximately, concentration of 2.5 g/dL provides a plasma oncotic pressure of 20 mm Hg and contributes to the equivalent of a total protein concentration of 5.2 g/dL.

2. The blood group A contains A antigens and produce anti B antibodies. The blood group B contains B antigens and produce anti A antibodies. The blood group AB contains antigens of both A and B and doesnot produce antibodies. Blood group O contains no antigens but capable of producing both anti A and B antibodies. If \'A\' antigen is removed from type A blood cells it can chage the pool of potential of AB recipients. The AB recipients should receive blood from only \'B\' group individuals but not from type \'A\' blood donors.