Select all TRUE statements Weak interactions are minimized i

Select all TRUE statements. Weak interactions are minimized in the reaction transition state Most of the binding energy comes from the formation of Weak bonds and interactions between an enzyme and its substrate Most enzyme-substrate interactions occur at the enzyme active site Binding energy is a major source of free energy used by enzymes to lower the activation energies of reactions Catalytic functional groups on an enzyme may form a permanent covalent bond with a substrate and activate it for a reaction

Solution

Weak interactions are minimized in the reaction transition state.

Explanation- There is optimization of weak interactions in the reaction transition state (at this stage, formation of substrate or product is equally likely).

Most of the binding energy comes from the formation of weak bonds and interactions between an enzyme and its substrate

Explanation- Lowering of activation energy is made possible through weak interactions between enzyme and substrate.

Most enzyme substrate interaction occur at the enzyme active site

Explanation- The substrates bind to the active of the enzyme. It is the site where a reactions are catalyzed.

Binding energy is a major source of free energy used by enzymes to lower the activation energy of reactions

Explanation- Binding energy is the energy derived from enzyme substrate interaction. It lowers activation energy.