Which of the following biochemical principles is not true of

Which of the following biochemical principles is not true of immunoglobulins as examples of protein structure and function?

a. Disulfide linkages strengthen the quaternary protein structure

b. Because the antigen-binding domain has high affinity, there is no observed induced fit.

c. Amino acid chain flexibility and bond rotation permit optimal epitope binding

d. There are two specific and identical binding sites with high affinity on the same molecule

e. There is 100% sequence homology between the two antigen binding sites.

Thank you!

Solution

Statement \'e\' is incorrect.

It is true that there are two antigen binding sites on one immunoglobulin molecule. Both these sites have extremely high affinity for antigen/epitope, but these can bind to different epitopes at the same time or to the same epitope. So, 100% sequence homology is not there.