24 What is the AG for the coupled reaction glucose glucose6p

24. What is the AG for the coupled reaction? glucose glucose-6-phosphate +ADP H ATP Show work and use Table 3.5 in your textbook. your

Solution

As per Table 3.5
glucose-6-phosphate + H2O Glucose + Pi: Go = -13.8
or Glucose + Pi glucose-6-phosphate + H2O :Go =13.8
ATP + H2O ADP + Pi + H+: Go = -32.2

So sum of coupled reaction ATP + glucose glucose-6-phosphate + ADP + H+ =13.8-32.2=-18.4

Hence Go\' for the coupled reaction is -18.4

However hexokinase mediated reaction ATP + glucose glucose-6-phosphate + ADP + H+ (phosphoryl transfer). Go = -4.0 kcal/mol