Why are developing thymocytes more likely to commit to the

Why are developing thymocytes more likely to commit to the : lineage than the : lineage?

Solution

T Cell Receptor (TCR), is a critical factor in determination of lineage.

There are many reasons behind more number of : lineage than : lineage, NOTCH receptor play important role in lineage determination.

Highest degree of : lineage is found in specific areas of the body like Gut Mucosa, Epidermal layer of the Skin, where these cells can give immunity without antigen processing and major-histocompatibility-complex (MHC) presentation.

In contrast to : T Cells which are part of innate immune system, : T Cells are more in number due to their function in adaptive immune system.

Many factors such as Erk-Egr-Id3 axis of the TCR, Id3 deficiency, reduced Notch activity favors the T cell.