Given that acetylation is a major player in the state of the

Given that acetylation is a major player in the state of the chromatin, describe the many ways it influences the chromatin.

Solution

Histone acetylation serves in regulation of gene expression by regulating the chromatin structure. Histone acetylation includes attachment of acetyl groups to lysines in histone tails. This neutralizes the positive charges on the tails redering them no longer able to bind to neighboring molecules. In this way, histone tails acetylation promotes loose chromatin structure and thereby permits the transcription. Histone acetylation also promotes initation of transcription by binding and recruiting components of transcription.