How does EPReffect facilitate passive targeting drug deliver

How does EPR-effect facilitate passive targeting drug delivery?

Solution

Answer- It had been observed that polymer and protein with large size and molecular weight tend to accumulation selectively in tumor cells and tissue in large amount as compared to normal tissue, moreover they retain in tumor tissue for longer periods. Solid tumor contain higher vascular density which is an important features of tumor to sustain their growth .Based on this specific property of tumor tissue a unique phenomenon developed which is known as enhanced permeability and retantion effect (EPR).

According to EPR effect macromoleculer drug retain in solid tumer for longer periods selectively and does not distribute to normal tissue.

EPR based chemotherapy thus becomes an important strategy to administer anti cancer drug at targated site.

In passive targeting drug delivery macromoleculer drugs are developed based on EPR effect including nanoparticles polymers, lyposomes , and Michelle. Therapeutic agents bind to this macromolecules are delivered to the tumer sites on the basis of EPR effect to cure cancer.