Regulation of expression by transcription factors and by alt

Regulation of expression by transcription factors and by alternative splicing are two different mechanisms of controlling gene expression in eukaryotes. What is the fundamental difference between the two?

Solution

okay let me explain

Regulation transcriptional factors (general transcription factors) generally control the levels of transcript produced in the cell sometimes(cell specific transcription factors ) they also control hetereochromatin and euchromatin state of a gene and thus control it epigenetically. They have nothing to do with alternative splicing which happens co-translationally, thus the function of transcriptional factors is to control amount of mRNA formed and has little to do with function.

Alternative splicing results in formation of different isoform mRNAs of a protien which could be specific for a particular cell type or differ in their isoform abundance. the control by alternative splicing is usually function and cell specific and isoforms could differ in their function and cellular location

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