What is the most direct effect of mutating the nuclear local

What is the most direct effect of mutating the nuclear localization signal of a protein? As a result of this mutation, the protein……

A. is translocated into the ER

B. is ubiquitinated and degraded

C. remains in the cytosol

D. is exported from the nucleus

E. binds tightly the nuclear pore

Solution

Option E. Binds tightly to the nuclear pore is the correct answer.

Mutation in the nuclear localization signal impairs the importin present in the nuclear pore and the proteins accumulate at the nuclear pores.