Immunology How is alternate splicing important in a Bcell Im

Solution

Alternative splicing a differential splicing is a regulated process during gene expression that results in a single tree in coding for multiple proteins in this process particular exams of a gene may be included within are excluded from the final process messenger RNA produced from that gene.

Alternative splicing is a process by which exons or portions of exons or non coding regions within a pre m-rna transcript are differentially joined or skipped resulting in multiple protein isoforms being encoded by a single gene this mechanism increases the informational diversity and functional capacity of gene during post transcriptional processing and provides an opportunity for regulation.

Alternate slicing can be tissue specific such that different proteins are made from the same original jeans by two or more different cell types. Or one cell type may make multiple configurations using the same gene. For instance a type of immune cell called a b-cell manufactures antibodies to numerous antigens. Antigens are foreign substances which Trigger immune responses and antibodies bind antigens so that they can be broken down and removed. Although and infinite number of antibodies can be produced all antibodies fall into one of 5 basic subtypes,alternative splicing is used to create these 5 antibody types from the same genes.

Alternative splicing is widely used in the memory and immune system to control the development and function of antigen specific lymphocytes. Mature B cells are the major antibody producing cells of the immune system. Alternative splicing of pre and RNA is prevalent in mammalian genome and acts as a mechanism to amplify Genetic diversity by enabling the number of proteins arising from the jeans to be increased by a factor of 10 times alternative pre-mrna splicing can also regulate protein expression in a Cell specific or tissue specific manner in response to precise environmental are developmental cues. Multiple variants of proteins isoforms can be produced from a single gene alternative splicing offers flexibility to the transcriptome and proteome to help fine tune important and complex cellular responses such as regulation of cell viability differentiation and apoptosis in response to environmental cues.