Which of the following domains is shared by all myosins ATPb

Which of the following domains is shared by all myosins? ATP-binding domain GTP-binding domain Tubulin binding domain Homo-oligomerization domain A central coiled coil domain How does the (-) end F-actin binding protein tropomodulin contribute to muscle contraction? It stabilizing the F-actin (-) end It blocks depolymerization at the (+) end O It blocks myosin binding It blocks ATP hydrolysis It blocks myosin movement towards the (+) end 3. Which of the following statements best describes the function of cofilin, a protein that destabilizes the (-) end of F-actin, during cell migration? It sequesters G-actin ATP It induces actin polymerization It promotes attachment of the leading edge to the substratum It induces the formation of a branched actin network at the leading edge Within the lamellipodium, it promotes actin network disassembly, freeing up G-actin subunit for assembly of a new action network 4. What is the effect of expressing a constitutively active form of the small GTPase Rac1 ? Cells depolymerize actin Cells form lamellipodial extensions Cells form stress fibers Cells form filopodia Cells form focal adhesions

Solution

Which of the following domains shared by all myosins

ATP binding domain-answer

All myosins share a generic motor domain that harbors the binding sites for ATP.

How does the (-) end F-actin binding protein tropomodulin contribute to muscle contraction

It stabilizing the Faction (-) end ---answer

It binds at the (-) end and stabilizes the filament.

Which of the following statement best describes the function of cofiln a protein that destabilises the (-) end of F-actin during cell migration

It induced action polymerisation-answer

What is the effect of expressing a constitutively active form of the small GTPASE Rac 1

Cell form lamellopodial extensions--answer

Rac1 : It is a little (~21 kDa) flagging G protein (all the more particularly a GTPase), and is an individual from the Rac subfamily of the family Rho group of GTPases. Individuals from this superfamily seem to direct a various exhibit of cell occasions, including the control of GLUT4[6] translocation to glucose take-up, cell development, cytoskeletal revamping, antimicrobial cytotoxicity, and the initiation of protein kinases.Rac1 is a pleiotropic controller of numerous cell forms, including the cell cycle, cell-cell bond, motility (through the actin arrange), and of epithelial separation (proposed to be vital for keeping up epidermal undifferentiated organisms).

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By controlling actin polymerization and depolymerization, the cell can make compels that create a few sorts of development. A great case is the development of a finger of film from the phone surface amid the acrosome response of an echinoderm sperm cell .. Later illustrations recommend that actin polymerization fortified by profilin is a typical instrument for producing the drive for development of intracellular pathogens and for cell velocity.