In the chart above the solid line represents hemoglobin oxyg

In the chart above, the solid line represents hemoglobin oxygen binding with NO drug treatment. Which curve above represents hemoglobin oxygen binding with drug treatment? (the dot one (right) or the dash one(left) ) . Please explain why.

Which state of hemoglobin would you predict the drug stabilizes, T or R? Explain.

How does the drug effect hemoglobin’s affinity for O2? Explain

Use the following information and chart to answer questions 13 16: Hospitals are looking for anyway to cut costs while maintaining quality of care. One arge expense is the delivery oxygen gas to patients, which increases tissues oxygenation levels in patients with impaired breathing function. A company is testing an injectable drug that they claim can increase the amount of oxygen to the tissues by binding to hemoglobin. po, in po in tissues. lungs 1.0 Hemoglobin (no drug) e 0.5 M 16 12 po2 (kPa)

Solution

The right dot curve represents hemoglobin oxygen binding with drug treatment. This is because the right shift in the curve represents reduced affinity of hemoglobin for oxygen which in turn leads to release of more oxygen to the tissues. The left curve exhibits increased oxygen affinity which would cause rather reduced oxygen delivery to the tissues.
The R state of hemoglobin has higher affinity for oxygen. So, the drug stabilize the T state.
The drug is stabilising the T state of hemoglobin which has the beta chains apart and a big central opening to ensure lower oxygen affinity.