If the proportion of an African population that are suscepti

If the proportion of an African population that are susceptible to Malaria is 0.24, what proportion of the population are affected with Sickle Cell Anemia?

A. 0.26.

B. 0.510.

C. 0.490.

D. 0.760.

E. 0.620.

Solution

Answer : A) 0.26

Explanation:

In Sub-Saharan African population the sickle cell anemia is an recessive genetic disorder.

AA - susceptible to Malaria

Aa - generally fine

aa - Sickle cell anemia disease.

- In the given question the proportion of African population susceptible to Malaria is 0.24.

According to Hardy-Weinberg equation, P² = AA = 0.24

P = 0.489

But P+Q = 1

Q = 1-P = 1-0.489 = 0.511

Q² = 0.261 = aa

Thus, the proportion of population effected with Sickle cell anemia is 0.26 (A option)