1You are given a drug to test and find that it increases the

1.You are given a drug to test and find that it increases the resting membrane potential and frequency of action potential firing. What are two possible drug targets and how could you differentiate them?

2.How is the resting membrane potential of a neuron established?

1. The two drug targets are 1. Na + ion channel, the passively transport Na+ ions from Extra Cellular Side (ECS) to Intra cellular space (ICS), which leads to Depolarization. 2. Na+ - K+ Pump: Active transporter that simultaniously transport Na+ ions from Intra cellular space to Extra Cellular Side and K+ ions from Extra Cellular Side to Intra cellular space and restores Resting Potential

2. In Neurons, ECS possess high amount of Na+ ions and ICS possess low Na+ ions. Due to this there ia existance of Resting Membrane Potential. While depolarization inorder to generate Action potential, the Na+ ions move from ECS to ICS. During this time, K+ ions also move from ICS to ESC. After the neuronal transmission, the exces ICS Na+ ions pumped out to ECS by Na+-K+ pump with the expense of ATP. dUE TO THIS PUMPING, RE ESTABLISHMENT OF RESTING POTENTIAL TAKES PLACE

1.You are given a drug to test and find that it increases the resting membrane potential and frequency of action potential firing. What are two possible drug t

1You are given a drug to test and find that it increases the

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