what is the connection between favism malarial resistance an

what is the connection between favism, malarial resistance and glucose-6-phosphate dehydrogenase activity?

Solution

The connection between favism, malarial resistance and glucose-6-phosphate dehydrogenase (G6PD) activity: G6PD is main enzyme responsible to work in oxidative phase of pentose phosphate pathway. Finally, this enzyme is going to convert nicotinamide adenine dinucleotide phosphate (NADP⁺) into NADPH. NADPH is a reduced form of NADP+ and NADPH is mainly crucial to exert malarial resistance by protecting red blood cells against oxidative stress. Therefore, it can be concluded that glucose-6-phosphate dehydrogenase deficiency is leading to higher sensitivity of RBC to H2O2 & other reactive oxygen species result in favism of G6PD Mediterranea & hemolytic anemia.