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Discuss appropriate clinical applications of amino acid prof

Discuss appropriate clinical applications of amino acid profiling. You may want to focus on a specific group of amino acids such as branched chain amino acids, amino acids involved in neurotransmitters, or sulfur-containing amino acids. Include a discussion of the appropriate specimen.
Discuss appropriate clinical applications of amino acid profiling. You may want to focus on a specific group of amino acids such as branched chain amino acids, amino acids involved in neurotransmitters, or sulfur-containing amino acids. Include a discussion of the appropriate specimen.

Solution

Amino acid profiling is extremely valuable in estabilizing nutritional therapies and understanding cellular and metabolic needs of a patients.

Branched chain amino acid- Breakdown of branched chain amino acid afforded an opportunity for detecting interruptions on the pathway caused by inadequacy of vitamin B6 and or other B vitamins. Leucine, Isoleucin and Valine are initially metabolized by enzyme and result in the deamination of keto-acids require for Vitamin B1,B2,B3,B5 and lipoic acid.

Amino acids involved in neurotransmitters- GABA is located in neurons. GABA in the plasmma is directly related to plasma ammonia concentration. Removal of ammonia via the urea cycle can be important clinical issue.

Sulfur containing amino acid- methionine and homocystein and involved in methionine metabolism. The cystathionine beta synthase is a mojor factor of this cycle made up of s containing proteins. The deficiency of this enzyme causes Homocystinuria, the most common genetic defect of sulfur containing amino acid.

Discuss appropriate clinical applications of amino acid profiling. You may want to focus on a specific group of amino acids such as branched chain amino acids,

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