Suggest how mutations affecting A the receptor itself B othe

Suggest how mutations affecting: A) the receptor itself; B) other proteins that bind to the receptor, and/or C) other proteins that work \'downstream\' of the receptor, might promote cancer.

Solution

MUTATION:A sudden change in the genetic material of the organism during the process of cell division is called mutation....

a)the receptor itself: In mutations, the androgen receptor affect the receptor itself,in the binding site of DHT.

b)other proteins that bind to the receptor:the mutations affect other proteins, in GP proteins mutations in the genes coding for GPCRs may lead to misfolding, altered plasma membrane expression of the receptor protein and frequently to disease.

c)other proteins that work down stream of the receptor,might promote cancer:The intracellular enzymes serve as downstream ,the G protein coupled receptor trigerring a down ward response that leads to relative to a particular molecule of interest.they causes the lung and ovary cancer.............................