1A mutation in a SNARE protein present on vesicles that disr

1-A mutation in a SNARE protein present on vesicles that disrupts it’s binding to Ca2+, thus ablating binding of the vesicle SNARE to the plasma membrane SNARE will (INCREASE or DECREASE) synaptic transmission. Why?

2-A mutation in the voltage-gated Ca2+ channel that caused the protein to mis-localize to dendritic membranes instead of axon terminals will (INCREASE or DECREASE) synaptic transmission. Why?

Solution

1. Decrease synaptic transmission

Main function of snare proteins is to help in vesicle docking and fusion (exocytosis) with their target membrane compartments and helps in synchronization of neurotransmitter release. Thus snare proteins regulate exocytosis and important for determining cooperative relationship between calcium and synaptic transmission.

2. Decreased synaptic transmission

Synaptic vesicle trafficking involves coordinated activity of proteins. Thus mislocalization of axonal proteins can result in missassembly (synaptic dysfunction)