Triclosan a common antimicrobial agent used in soaps targets

Triclosan, a common antimicrobial agent used in soaps, targets the second reductase in bacterial FAS. What would the product of FAS look like after the addition of 1 malonyl CoA, 1 acetyl CoA, XS NADPH and triclosan?

Solution

Answer:

Triclosan at high concentrations act as bacteriostatic which interferes with the fatty acid synthesis. Triclosan binds

to bacterial enoyl-acyl carrier protein reductase (ENR) enzyme which is encoded by the gene FabI. This binding

enhances the enzyme\'s affinity for nicotinamide adenine dinucleotide (NAD⁺). This results in the formation of a

stable ternary complex of ENR-NAD⁺-triclosan, which is unable to participate in fatty acid synthesis.